Research Grants

Exploring the TNFRSF14 locus in Follicular Lymphoma

Role Involved : Principal Investigator
Other Investigators: Douglas Stewart, Etienne Mahe, Ariz Akhter
(Co-I’s)
Agencies : Alberta Precision Labs
Total Award : $6,000.00 (2021)

Pan Canadian harmonization of Immunohistochemistry

protocols for cell of origin classification of diffuse large B-cell lymphoma (DLBCL)
Role Involved : Co- Principal Investigator
Other Investigators : Emina E. Torlakovic (Co-PI)
Agencies : Jensen Canada/ Johnson & Johnson Research Fund
Total Award : $56,430 (2017 – 2020))

Prognostic biomarkers through gene expression in non-Hodgkin

lymphoma such primary CNS and Testicular lymphoma arising at Immune privileged sites
Role Involved : Co- Principal Investigator
Other Investigators : Carolyn Owen (Co-PI), Stewart D (Co-PI);
Agencies : Calgary Health Trust Hematology Education and Research Fund
Total Award : $65,000 (2016 - 2017)

Prediction of prognosis in myeloid neoplasms

Prediction of prognosis in myeloid neoplasms through next generation sequencing platform; validation of myeloid panel.
Role Involved : Co- Investigator
Other Investigators : Faisal Khan (Co-PI), Meer-Taher Shabani-Rad (Co-PI);
Agencies : Calgary Health Trust Hematology Education and Research Fund
Total Award : $85,000 (2016 - 2017)

Development of a Tissue-based & Cell-Free

DNA (cfDNA) Next-Generation Sequencing (NGS) Workflow
Role Involved : Co-Investigator
Other Investigators : Etienne Mahe (PI), Meer-Taher Shabani-Rad (Co-Inv)
Agency : Calgary Laboratory Services (CLS) Research Fund
Total Award : $45,000.00 (2016 – 2018)

Prognostic Significance of MN1, ERG, BAALC and EVI1 (MEBE) Expression

Signature in Various Cytogenetic Risk Groups Among Patients with Acute Myeloid Leukemia
Role Involved : Principal Investigator
Other Investigators : Ariz Akhter (Co-PI), Meer-Taher Shabani-Rad, Fariborz Kolvear
Agency : Calgary Laboratory Services (CLS) Research Fund
Total Award : $9,853.00 (2015 – 2017)

Role of Natural Killer Cells Receptor genes

Role of Natural Killer Cells Receptor genes in the immunopathogenesis and prognosis of different types of Lymphoma.
Role Involved : Co-Investigator
Other Investigators: Faisal Khan (PI), Douglas Stewart
Agency : Alberta Cancer Foundation
Total Award : $97,125 (2015-2018)

Validation of “nCounter Leukemia Fusion Gene

Expression AssayKit” by Nanostring technologies to determine multiple genetic aberrations for classification of Acute Leukemia.
Role Involved: Co-Principal-Investigator
Other Investigators: Meer-Taher Shabani-Rad (co-PI); Fahad Farooq
Agency: Calgary Laboratory Services (CLS) Research Fund
Total Award : $9,800 (2014 - 2016)

Predict Benefit and Improve Outcomes of Conventional High Dose

Therapy/Stem Cell Transplantation for Lymphoma Patients through Molecular Biomarkers
Role Involved :Co-PrincipalInvestigator
OtherInvestigators : StewartD(Co-PI);Owen C (Co-PI)
Agencies : Alberta Cancer Foundation (ACF) /Stephure Directed Donation
Total Award : $200,000 (2014 - 2016)

Follicular lymphoma: Identifying a “Proliferative Molecular Signature”

: Follicular lymphoma: Identifying a “Proliferative Molecular Signature” as a predictor of aggressive clinical disease and its validation through routine immunohistochemistry techniques
Role Involved : Co- Principal Investigator
Other Investigators : Stewart D (Co-PI), Mahe E, Danielle Oh, Akhter A
Agencies : Calgary Health Trust Hematology Education and Research Fund
Total Award : $15,000 (2014 - 2016)

“Metabolomics Profiling of Follicular Lymphoma"

Role Involved : Co-Investigator
Other Investigators : Stewart D (PI), Meer-Taher Shabani-Rad,
Agencies : Calgary Health Trust / Hematology Education and Research Fund
Total Award : $15,000 (2014 - 2016)

Reovirus as a viable therapeutic

Reovirus as a viable therapeutic option to target therapy resistance of multiple myeloma
Role Involved : Co-Investigator
Other Investigators : Morris, D (PI), Thirukkumaran C
Agencies : Cancer Research Society
Total Award : $120,000 (2013 - 2015)

Hematological profile, appropriate for gestational

Hematological profile, appropriate for gestational age infants born to mothers with early onset preeclampsia
Role involved : Co-investigator
Other Investigators : Kamran Yusuf (PI)
Agencies : Alberta Children’s Hospital Research Institute (ACHRI)
Total Award : $2,985 (2013 - 2014)

Toward improved outcomes of antithymocyte

Toward improved outcomes of antithymocyte globulin-conditioned hematopoietic cell transplantation
Role Involved : Collaborator
Other Investigators : Storek J (PI) , Khan F, Morris D, Daly A, Larratt L, Preiksaitis J,
Agencies : Alberta Innovates – Health Solutions (AIHS)- CRIO grant
Total Award : $750,000 (2011 - 2013)

Predicting benefit of standard treatment and personalize

Predicting benefit of standard treatment and personalize medicine for relapse/refractory diffuse large B-cell lymphoma using genetic and proteomic testing
Role Involved :Co-Principal Investigator
Other Investigators :StewartD(Co-PI),Bosch,M
Agencies : Calgary Health Trust / Hematology Education and Research Fund
Total Award : $40,000 (2012 - 2013)

Creation of a Lymphoma Tissue Bank

Creation of a Lymphoma Tissue Bank through Establishing a Cancer Research Fellowship
Role Involved :Co-PrincipalInvestigator Other Investigators: Stewart D (Co-PI),
Agencies : Alberta Cancer Foundation / Stephure Directed Donation
Total Award:: $250,000 (2012 - 2014)

Predicting benefit of salvage and high dose chemotherapy with autologous

stem cell transplantation for relapsed Diffuse Large B-cell Lymphoma patients through tissue array based biomarker classifications.
Role Involved : Co-Principal Investigator
Other Investigators : Stewart D (Co-PI), Mark Bosch
Agencies : Alberta Cancer Foundation/ Directed Donation
Total Award : $41,302 (2011 - 2012)

Expression of CD-20-related genes in Lymphocytic Neoplasm

Role Involved : Co-investigator
Other Investigators : Julie Deans (PI), Iwona Auer, Doug Stewart, Doug Demetrick
Agencies : CIHR
Total Award : $152,875 (2008 - 2011)

Prediction of outcomes of HCT using novel immune assays

Role Involved : Co-investigator
Other Investigator : Storek J (PI)
Agencies : ACRI Operating Grant
Total Award : $452,633 (2008 - 2009)

Therapeutic Targets and Prognostic Markers for Mantle cell lymphoma

Role Involved : Co-investigator
Other Investigator : Dr. Lai R (PI), Stewart D Agencies: CIHR
Total Award : $330,000 (2008-2011)

Tissue-Based Array Classification of Multiple Myeloma.

Role Involved : Collaborator
Other Investigator : Klimowicz A, Bahlis N (PI)
Agencies : Multiple Myeloma Research Foundation
Total Award : $75,000 (2008 – 2009)

Predicting benefit and improving outcomes of high dose therapy (HDT)

Predicting benefit and improving outcomes of high dose therapy (HDT) and autologous stem cell transplantation for myeloma patients through tissue arrays based classification.
Role Involved :Co-Principal Investigator
Other Investigator : StewartD(Co-PI); BahlisN(Co-PI)
Agencies : Terry Fox Research Institute and Alberta Cancer Foundation
Total Award : $1,315,107 (2008 - 2011)

An “observer-independent” and fully quantitative Tissue Microarray

An “observer-independent” and fully quantitative Tissue Microarray (TMA) based classification is predictive of survival among Multiple Myeloma (MM) patients
Role Involved :Co-Principal Investigator
OtherInvestigator : StewartD;BahlisN(Co-PI)
Agencies :Calgary Laboratory Services
Total Award : $9,950 (2008 – 2011)

Tissue Based Array Classification of Multiple Myeloma

Role Involved : Collaborator
Other Investigator : Stewart D; Bahlis N (PI)
Agencies : Alberta Cancer Board Research Funding Committee (ACB-RFC)
Total Award : $35,000 (2007

Validation of interphase FISH (Fluorescent in-Situ Hybridization)

Validation of interphase FISH (Fluorescent in-Situ Hybridization) and immunohistochemical staining as prognostic tools in Multiple Myeloma patients undergoing autologous stem cell transplantation
Role Involved : Co-Principal Investigator
Other Investigator : Stewart D; Bahlis N (Co-PI)
Agencies : Calgary Laboratory Services
Total Award : $7,500 (2007 - 2009)

Weight-Adjusted Dosing of Tinzaparin in Pregnancy

Role Involved : Co-Investigator
Other Investigator : Gibson, P (PI)
Agencies : Leo Pharma
Total Award : $29,000 (2007 - 2009).

Tissue and RT-PCR-based Classification of Multiple Myeloma

Role Involved : Co-investigator
Other Investigator : Stewart D; Bahlis N (PI)
Agencies : Research/Education Fund – Div. of Hematology, University ofCalgary,
Total Award : $32,000 (2006 - 2007).

Detection of CD25 as a Surrogate Marker for Prognosis

Detection of CD25 as a Surrogate Marker for Prognosis of Patients with Mutated or Unmutated B-Cell Chronic Lymphocytic Leukemia (CLL)
Role Involved : Co-Principal Investigator
Other Investigator: Howell, J (Co-PI)
Agencies : Leukemia and Lymphoma Society of Canada
Total Award : $5,000 (2006)

Frontline: Evaluation of predictive markers

Frontline: Evaluation of predictive markers among aggressive Non-Hodgkin Lymphomas treated with Double High Dose Chemother
Role involved : Co-Principal Investigator
Other Investigators : StewartD(Co-PI)
Funded : Research / Education Fund – Division of Hematology, University of Calgary,
Total Award : $10,000 (2005 – 2006)

Validating p-PKCd, p-AKT and PTEN as Prognostic Markers in Multiple Myeloma.

Role Involved : Co-Principal Investigator
Other Investigator : StewartD;BahlisN(Co-PI)
Agencies : Calgary LaboratoryServices
Total Award : $7,360 (2004 -2007).

Expression of TIMP-1 and STAT3 in Diffuse Large B-cell Lymphomas.

Role involved : Principal Investigator
Other Investigator : Stewart D; Bahlis N
Agencies : Calgary Laboratory ServicesTotal
Award : $6,500 (2003 - 2006).

Comparison of PT/INR values by Point-of-Care (Coagu-check) and MLA-1800 methods, among Acute Stroke patients.

Role involved : Co-Investigator
Other Investigator : Lyon, M (PI)
Agencies : Calgary Laboratory Services Total
Award : $5,500 (2004 - 2006)